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. 2017 Jun 2;14:16. doi: 10.1186/s12987-017-0064-3

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Case 3; Axial T1-weighted post contrast imaging at initial presentation (a, b), after completing therapy with HD-MTX (c) and relapse (d). Initial presentation shows a large enhancing lesion in the left frontal lobe (a) and normal cerebellum (b). Patient was in complete response after completing 1 year of HD-MTX treatment (c) with radiographic relapse in the right cerebellum, 6 years after the initial diagnosis (d)