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. 2017 Apr 12;6(4):e22. doi: 10.1038/emi.2017.30

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Copyright © 2017 The Author(s)

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RVs recognize histo-blood group antigens (HBGAs). A total of 35 RV genotypes (P[1]–P[35]) in five genogroups (P[I]–P[V]) based on the VP8* sequences of the viral capsid structural protein VP4 have been classified following phylogenetic analysis.³⁴ The potential target hosts for individual genotypes are indicated based on the frequencies of sequences found for individual genotypes in each species. The carbohydrate ligands or receptors for individual RV genotypes are based on recent publications,^{34, 35, 36, 37} but such data for most animal RVs remain unknown. The finding that RV Wa recognizes an internal SA is not indicated in the figure. The horizontal bar indicates the number of substitutions per amino acid. Sialic acid dependent (Sia).