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. 2016 Dec 23;24(3):469–480. doi: 10.1038/cdd.2016.143

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Copyright © 2017 The Author(s)

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Pellino-1-Tg mice develop lung cancer and Pellino-1 is overexpressed in human lung cancers. (a) Representative macroscopic images showing lung tumors (arrows) in Pellino-1-Tg mice (top). Lysates of non-Tg and Pellino-1-Tg lung tissues were subjected to immunoblotting for Pellino-1 and actin (bottom). (b) Microscopic images for lung adenocarcinoma (F3-31), dysplasia (F2-35) and AAH-like lesions (F5-106) developed in Pellino-1-Tg mice. (c) Representative IHC images for Pellino-1 in normal human lung tissues (upper) and lung cancers (middle and lower) (original magnification, × 400). Pellino-1 expression rate was analyzed according to the histological subtype of human lung cancer including adenocarcinoma, squamous cell carcinoma and other NSCLC histology (bottom table). (d) Two non-tumor human lung cell lines (BEAS-2B and WI-26) and 17 human lung cancer cell lines (all adenocarcinomas except for H460) with WT EGFR or mutated EGFR were analyzed for Pellino-1 expression using immunoblotting (top). Pellino-1 expression level was quantified through scanning densitometry with actin as an internal control (bottom)