Table 2. Protein signatures in different grades of glioma^{10,11,12,13,14,15,16}.

Glioma gradation	Proteins over-expressed	Proteins down-regulated
Low Grade	AHSG, PDI A3, αB-crystallin, enolase, glutamate dehydrogenase I, phosphopyruvate hydratase, protein disulfide isomerase A3, cyclin-dependent kinase inhibitor 1 (p21), CDKN1A, glutathione S transferase P	cAMP response element-binding protein-1, GRP78, Rac1, and RhoA, cystatin B, MVP
Grade II	Astrocytic phosphoprotein PEA 15, UCHL1, CDKN1A
High Grade	Galectin-1, GFAP, IGFBP2/5, PBEF1/NAmPRTase, PAI-1, Cathepsin-D, YKL-40, MMP-9, 1-CaD, RalA, Rab3B, nucleolar GTP-binding proteins, GRP78, RhoA, Rac1, Ezrin, protein kinase C γ, MAPKa/ERK kinase 1, Rac 1, prohibitin, phosphoglycerate mutase 1, glutathione S-transferase M, RAB3A, Ras-related protein Ral-A, transforming protein Rho A	TTR AHSG
Grade III	Astrocytic phosphoprotein PEA 15, fatty acid binding protein 5, HSP 27, ferritin, eukaryotic initiation factor 4A (p37)
Grade IV (GBM)	CREB, peroxiredoxin 1 and 6, α-internexin, BTF3, calcyclin, calpactin I light chain, tubuline-specific chaperone A, Calnexin, AnxA2, AnxA5, GFAP, transcription factor Sp2, DRP-2, large proline-rich protein BAT2, Cystatin B, MVP, HSP 27 eukaryotic initiation factor 4A (p37)	DI A3, UCHL1; PKA
Primary GBM	Tenascin precursor, Enolase-1, centrosome associated protein 350, EGFR
Secondary GBM	ERCC6, DUOX2, Wnt-11 precursor, Cadherin-related tumor suppressor homolog precursor, ADAMTS-19, hnRNP A3, ERCC6, DUOX2