Figure 9.

AA13 inhibited dimethylbenzene-induced ear edema in mice. Mice were randomly assigned into three groups: Model; Antifani (10 mg/kg) and AA13 (20 mg/kg). Dimethylbenzene was applied on inner and outer surface of right ears of mice to induce edema 1 h after the last drugs or vehicle administration. Edema was determined as weight difference between the biopsies from right ear (dimethylbenzene treated) and the left ear (untreated control) (B). Histological alteration was detected by hematoxylin and eosin staining (A) and observed under microscope. Mean±SEM. n=5 independent experiments. ^*P<0.05 vs control group.