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. 2017 Mar 20;38(5):710–718. doi: 10.1038/aps.2016.161

Figure 4.

Figure 4

PD-1 receptor occupancy and PK profiles. (A) PD-1 RO experiment was performed by FCA; a detailed description is available in Materials and Methods. Long-term PD-1 occupancy analysis in the four groups. *P<0.05, **P<0.01 vs H. #P<0.05 vs HP1. Data are shown as the mean±SD from 3 independently analyzed monkeys. (B) Drug concentration time curves of cynomolgus macaques after a single vd administration of JS-001 at low, mid, and high dosages (mean±SD, n=6). (C) Drug concentration-time curves of cynomolgus macaques after successive vd administrations of 10 mg/kg JS-001 (mean±SD, n=6).