Table 1. PK parameters of JS-001 after single vd administrations of 1, 10, and 75 mg/kg in cynomolgus macaques (mean±SD, n=6).

PK parameters	Units	Group 2 1 mg/kg	Group 3 10 mg/kg	Group 4 75 mg/kg
t1/2_7 d	h	133.91±19.50	168.87±50.96	193.79±27.5*
t1/2_14 d	h	64.48±41.70	114.16±42.82	156.32±53.99*
t1/2a	h	35.13±16.14	36.82±4.75	34.96±5.74
Tmax	h	0.5±0	0.5±0	0.5±0
Cmax	μg/mL	27.70±12.29	216.11±34.52**	1891.72±270.16**,##
AUC(0–t)	h·μg·mL−1	2744.55±834.19	31075.53±9849.79**	269472.4±50585.96**,##
AUC(0–inf)	h·μg·mL−1	2749.51±833.39	31096.05±9849.95**	269488.17±50574.79**,##
AUC(t–inf)%	%	0.20±0.26	0.07±0.06	0.01±0.01#
Vd	mL/kg	18.22±3.77	17.94±3.63	14.28±2.54
CLs	mL·h−1·kg−1	0.39±0.12	0.35±0.09	0.29±0.05
MRT	h	121.91±38.84	147.5±62.6	149.25±24.68

note: t_{1/2_7 d} and t_{1/2_14 d}, effective half-time, which was calculated by terminal phase data harvested from the first 7 or 14 d;

^a t_1/2: terminal t_1/2, calculated by total terminal phase data;

*P<0.05,

**P<0.01 vs Group 2;

^#P<0.05,

^##P<0.01 vs Group 3.