Table 2. PK parameters of JS-001 after successive administrations of 10 mg/kg in cynomolgus macaques (mean±SD, n=6).

PK parameters	Units	First	Group 1 vd JS-001 10 mg/kg Last (0–168 h)	Last (0–inf)
t1/2	h	175±11.82	39.8±25.06**	37.6±25.83
Tmax	h	1.75±3.06	0.5±0	0.5±0
Cmax	μg/mL	205.82±51.71	185.6±44.21	185.6±44.21
AUC(0–t)	h·μg·mL−1	16513.89±1212.45	8310.92±6404.33*	9794.67±8406.78
AUC(0–inf)	h·μg·mL−1	34408.03±3689.04	9558.99±8170.37**	9816.77±8386.49
AUC(t–inf)%	%	51.85±1.92	7.80±7.78**	0.92±2.20
Vd	mL/kg	73.72±4.79	73.24±23.95	67.74±25.87
CLs	mL·h−1·kg−1	0.29±0.03	2.07±1.71*	2.05±1.72
MRT	h	252.9±13.75	52.83±35.25**	55.9±39.66
ARa	NA	NA	0.50±0.37	NA

^a AR: accumulation rate, last drug administration AUC_{(0–168 h)}/ first drug administration AUC_{(0–168 h)};

*P<0.05,

**P<0.01 vs Group 1 first administration.