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. 2017 Mar 6;38(5):688–698. doi: 10.1038/aps.2016.168

Figure 4.

Figure 4

Effects of geniposide on intestinal permeability in TNBS-treated rats. (A) Geniposide (L, 25 mg/kg) and geniposide (H, 50 mg/kg) reduced the increase in the serum recovery of FD-4 induced by TNBS. Data are expressed as the mean±SD. n=6. (B) Geniposide reversed the increase in myosin light chain kinase (MLCK) protein level induced by TNBS. (C) Geniposide (25, 50 mg/kg) treatment reversed the decrease in AMP-activated protein kinase (AMPK) protein phosphorylation triggered by TNBS. (D) Geniposide reversed the reduction in the expression of tight junction proteins (occludin and ZO-1) induced by TNBS. Data are expressed as the mean±SD. n=3. **P<0.01 vs vehicle control group. #P<0.05, ##P<0.01 vs TNBS-treated group.