(A) Spleen, EPHARNA treated mouse, control probe; (B) Spleen, EPHARNA treated mouse, anti-siRNA probe; (C) CNS, EPHARNA treated mouse, control probe; (D) CNS, EPHARNA treated mouse, anti-siRNA probe; (E) Spleen, Control DOPC treated mouse, control probe (F) Spleen, control DOPC treated mouse, anti-siRNA probe; (G) CNS, control DOPC treated mouse, control probe; (H) CNS, control DOPC treated mouse, anti-siRNA probe