Table 1.

Hematologic parameters after twice weekly EPHARNA administration in mice. EPHARNA appeared to cause a mild, dose dependent inflammatory response.

	EPHARNA dose group
	0 mg/kg		0.3 mg/kg		0.6 mg/kg
	Male (n=4)	Female (n=5)	Male (n=5)	Female (n=5)	Male (n=4)	Female (n=5)
WBC (SD)	5.720 (1.220)	7.382 (1.759)	5.840 (1.208)	8.332 (1.018)	8.734 (1.656)	8.636 (2.840)
Absolute Neutrophil	0.888 (0.253)	0.908 (0.205)	0.854 (0.148)	1.170 (0.290)	1.076 (0.212)	1.200 (0.401)
Absolute Monocyte	0.175 (0.083)	0.282 (0.217)	0.290 (0.135)	0.774 (0.240)	0.524 (0.271)	0.840 (0.215)
Absolute Lymphocyte	4.535 (1.274)	6.036 (1.906)	4.552 (1.041)	6.092 (0.768)	6.958 (1.500)	6.302 (2.558)
Absolute Eosinophil	0.116 (0.111)	0.154 (0.127)	0.146 (0.036)	0.296 (0.231)	0.178 (0.269)	0.278 (0.216)
RBC	9.67 (0.261)	9.35 (0.664)	9.52 (0.289)	9.19 (0.493)	9.70 (0.440)	9.12 (0.210)
Hgb	15.1 (0.46)	14.9 (1.03)	15.44 (0.61)	14.76 (0.85)	15.30 (0.58)	14.30 (0.71)
HCT	52.0 (1.30)	50.2 (2.96)	52.1 (1.15)	49.4 (2.70)	51.1 (1.70)	46.92 (1.94)
MFCV	53.85 (0.97)	53.74 (0.94)	54.70 (1.15)	53.78 (1.09)	52.72 (0.55)	51.46 (0.40)
MCHC	15.63 (0.26)	15.98 (0.49)	16.18 (0.33)	16.08 (0.45)	15.76 (0.55)	15.66 (0.58)