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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2017 Mar 3;16(6):1080–1091. doi: 10.1158/1535-7163.MCT-16-0626

Figure 3. G-1 disrupts microtubule assembly in vivo.

Figure 3

Representative high-resolution images showing microtubule structures (red) of MDA-MB-231 and MCF7 cells incubated in the presence or absence of vehicle (0.1% DMSO), paclitaxel (10 μM), nocodazole (10 μM), or G-1 (10 μM) for 2 h. Representative high-resolution image (focusing on a single cell) in each groups was presented in the middle panels to show the detail of the microtubule structure. The low magnification image with multiple cells in each group was also presented (on the according side). Scale bar = 10 μm. Paclitaxel stabilizes microtubule, while G-1, similar to nocodazole, disrupts microtubule formation.