Table 2. Histopathologic Worsening Multivariate Cox Proportional Hazard Ratio Analysis.

Upper section evaluates time to ESRD, adjusting for multiple factors and lower evaluates time to death.

ESRD
Parameter Description	Regression Coefficient	p-Value	Hazard Ratio
Age at First Renal Biopsy
Age 18–50		ref.	ref.
Age<18 & Age>50 at First Renal Biopsy	−1.036	0.037	0.355
Gender
Female		ref.	ref.
Male	0.091	0.830	1.095
Race/Ethnicity
White		ref.	ref.
Hispanic Ethnicity	0.620	0.325	1.859
Black Race	0.458	0.459	1.580
First Biopsy Histopathologic Classification
Mesangial (II)		ref.	ref.
Membranous (V)	0.873	0.291	2.395
Proliferative (III, IV, III+V, IV+V)	1.484	0.048	4.411
Induction Therapy
Other (AZA, CYA)		ref.	ref.
CYC	0.208	0.845	1.231
MMF	0.438	0.681	1.549
None or Unknown Induction Therapy	−0.464	0.689	0.629
Second Biopsy Compared to First
Same or Improved		ref.	ref.
Worse	1.426	0.0001	4.160

DEATH
Parameter Description	Regression Coefficient	p-Value	Hazard Ratio
Age at First Renal Biopsy
Age 18–50		ref.	ref.
Age<18 & Age>50 at First Renal Biopsy	−0.562	0.281	1.754
Gender
Female		ref.	ref.
Male	0.495	0.397	1.641
Race/Ethnicity
White		ref.	ref.
Hispanic Ethnicity	0.049	0.954	1.050
Black Race	0.206	0.796	1.229
First Biopsy Histopathologic Classification
Mesangial (II)		ref.	ref.
Membranous (V)	0.185	0.835	1.203
Proliferative (III, IV, III+V, IV+V)	0.108	0.895	1.114
Induction Therapy
Other (AZA, CYA)		ref.	ref.
CYC	0.377	0.746	1.457
MMF	0.312	0.799	1.366
None or Unknown Induction Therapy	1.165	0.344	3.206
Second Biopsy Compared to First
Same or Improved		ref.	ref.
Worse	1.458	0.022	4.297