Table 3.

Time In Years Between First and Second Biopsies Multivarite Cox Proportional Hazard Ratio Analysis.Upper section evaluates time to ESRD, adjusting for multiple factors and lower evaluates time to death.

ESRD
Parameter Description	Regression Coefficient	p-Value	Hazard Ratio
Age at First Renal Biopsy
Age 18–50		ref.	ref.
Age<18 & Age>50 at First Renal Biopsy	−0.162	0.773	0.850
Gender
Female		ref.	ref.
Male	0.267	0.517	1.307
Race/Ethnicity
White		ref.	ref.
Hispanic Ethnicity	0.997	0.121	2.711
Black Race	0.832	0.190	2.298
First Biopsy Histopathologic Classification
Mesangial (II)		ref.	ref.
Membranous (V)	0.869	0.294	2.385
Proliferative (III, IV, III+V, IV+V)	1.339	0.070	3.815
Induction Therapy
Other (AZA, CYA)		ref.	ref.
CYC	0.777	0.466	2.174
MMF	0.634	0.555	1.886
None or Unknown Induction Therapy	−0.196	0.867	0.822
Time Between First and Second Biopsies
>5 Years		ref.	ref.
<1 Year	2.614	0.0001	13.65
>1–5 Years	1.530	0.0028	4.619

DEATH
Parameter Description	Regression Coefficient	p-Value	Hazard Ratio
Age at First Renal Biopsy
Age 18–50		ref.	ref.
Age<18 & Age>50 at First Renal Biopsy	1.221	0.027	3.391
Gender
Female		ref.	ref.
Male	0.743	0.218	2.102
Race/Ethnicity
White		ref.	ref.
Hispanic Ethnicity	0.092	0.913	1.097
Black Race	0.340	0.671	1.405
First Biopsy Histopathologic Classification
Mesangial (II)		ref.	ref.
Membranous (V)	0.343	0.699	1.409
Proliferative (III, IV, III+V, IV+V)	0.042	0.958	1.043
Induction Therapy
Other (AZA, CYA)		ref.	ref.
CYC	1.053	0.383	2.866
MMF	0.711	0.576	2.095
None or Unknown Induction Therapy	1.847	0.143	6.340
Time Between First and Second Biopsies
>5 Years		ref.	ref.
<1 Year	2.825	0.002	16.860
>1–5 Years	2.093	0.011	8.106