TABLE II.
Associations between mouse sensitization and severity score and treatment step
| CASI score*
β (95% CI) P value |
Treatment stepf β (95% CI) P value |
Prebronchodilator FEV1/FVC 85%‡
OR (95% CI) P value |
Post-FEV1/FVC <85%§
OR (95% CI) P value |
|||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|||||
| Mouse sensitization variable | Crude | Adjusted∥ | Crude | Adjusted∥ | Crude | Adjusted∥ | Crude | Adjusted∥ |
| Wheal size (mm) |
0.10 (0.01 to 0.18)
P = .02 |
0.07 (−0.03 to 0.17) P = .17 |
0.06 (0.02 to 0.10)
P = .002 |
0.03 (−0.02 to 0.07) P = .21 |
1.05 (1.00 to 1.11)
P = .045 |
1.01 (0.95 to 1.08) P = .68 |
1.05 (0.99 to 1.12) P = .10 |
1.02 (0.94 to 1.10) P = .68 |
|
| ||||||||
| log2(IgE) (kU/L) |
0.10 (0.03 to 0.16)
P = .003 |
0.08 (0.01 to 0.15)
P = .04 |
0.06 (0.03 to 0.09)
P < .001 |
0.03 (0.001 to 0.06)
P = .04 |
1.01 (0.97 to 1.05) P = .64 |
1.00 (0.95 to 1.04) P = .89 |
1.00 (0.96 to 1.06) P = .87 |
0.98 (0.92 to 1.04) P = .50 |
|
| ||||||||
| +SPT or +IgE |
0.92 (0.36 to 1.49)
P = .001 |
0.82 (0.16 to 1.47)
P = .02 |
0.56 (0.31 to 0.81)
P < .001 |
0.36 (0.07 to 0.64)
P = .01 |
1.43 (1.02 to 1.99)
P = .04 |
1.16 (0.78 to 1.74) P = .46 |
1.40 (0.92 to 2.13) P = .12 |
1.11 (0.67 to 1.86) P = .68 |
SPT, Skin prick test.
*
n = 591 for wheal size and +SPT/IgE, n = 581 for log2(IgE).
†
n = 645 for wheal size and +SPT/IgE, n = 635 for log2(IgE).
‡
n = 596 for wheal size and +SPT/IgE, n = 586 for log2(IgE), n values for crude models.
§
Restricted to participants 8 y and older because Hankinson equations are valid down to 8 y. n = 381-382 for wheal size and +SFl7IgE, n = 375-376 for log2(IgE).
∥
Adjusted for age, sex, insurance, site, atopy (number of positive skin test results excluding mouse), race, and Hispanic ethnicity.