Table 4. Relevant high specificity cut-offs and sensitivities for best regional variables tested.

Best regional variables	AUC	99% specificity cut-off	Sensitivity at 99% specificity	95% specificity cut-off	Sensitivity at 95% specificity (%)
GSDI	0.922*	0.80	69%	0.60	80.2
VCDR	0.867	0.85	51.5%	0.79	63.3
GCC FLV	0.844	3.9%	52.1%	2.3%	65.7
NFL FLV	0.884	8.3%	43.2%	5.1%	64.0
GCC GLV	0.886	11.6%	52.5%	9.3%	61.4
NFL GLV	0.896	23.1%	38.1%	14.5%	68.6
GCC overall	0.866	84.0 μ	50.0%	85.7 μ	56.4
NFL overall	0.894	76.5 μ	36.4%	86.1 μ	64.8

^*The AUC, sensitivity and specificity for GSDI were calculated using leave-one-out cross-validation.

AUC, area under the receiver operator characteristic curve; FLV, focal loss volume; GCC, ganglion cell complex; GLV, global loss volume; GSDI, glaucoma structural diagnostic index; NFL, nerve fibre layer; VCDR, vertical cup-to- disc ratio.