Table 1.
Artificial chromosome segregation errors
| Number (%) of chromosome mis-segregation events* | ||||||||
| Line | Number of cells analyzed | Artificial | NDJ | Lag | Host 17 | Host X | NDJ | Lag |
| 17-B12 | 86 | 5/208 (2.4) | 3 | 2 | 3/295 (1.0) | 2 | 1 | |
| 17-C20 | 224 | 91/745 (12.2)† | 31 | 60 | 13/884 (1.5) | 9 | 4 | |
| X-4‡ | 400 | 16/866 (1.8) | 10 | 6 | 25/1,596 (1.6) | 20 | 5 | |
| X-5‡ | 400 | 43/1,954 (2.2) | 30 | 13 | 4/1,588 (0.2) | 4 | 0 | |
*Chromosome segregation errors (either artificial chromosomes or host chromosomes 17 or X) were nondisjunction (NDJ) or anaphase lag (Lag) events. †The predominant artificial chromosome segregation error in 17-C20 was due to anaphase lag (66%, n = 91). ‡Data for X-4 and X-5 have been published [14]. Segregation errors that could not be classified (for example, 1:0) were excluded from these analyses.