Table 1.
Myocardial T1 values at selected ROI (LV inter-septal region) in 8 healthy volunteers measured by the MOLLI sequence using four different T1 estimations algorithms.
| MOLLI | Myocardium | BLESSPC | InSiL | IG fit4 | Original fit4 |
|---|---|---|---|---|---|
| 5(3)3, 35° | T1 (ms) | 1167.9±23.1 | 1165.5±22.9 | 1092.7±24.2 | 1095.9±22.4 |
| 5(0)3, 35° | T1 (ms) | 1166.2±34.8 | 1165.2±34.8 | 1089.9±31.1 | 1000.4±31.6* |
| Difference 1 | (−0.2%±1.8%) | (−0.0%±1.8%) | (−0.3%±1.2%) | (−8.7%±1.7%) | |
| 4(1)3(1)2, 35° | T1 (ms) | 1161.6±23.7 | 1157.9±23.3 | 1090.1±22.4 | 1039.3±26.5* |
| Difference 1 | (−0.5%±1.2%) | (−0.6%±1.2%) | (−0.2%±1.9%) | (−5.2%±2.0%) | |
| 5(3)3, 20° | T1 (ms) | 1150.8±26.9* | 1145.0±27.0* | 1123.0±31.3* | 1117.1±26.1* |
| Difference 1 | (−1.5%±1.3%) | (−1.8%±1.3%) | (2.8%±1.3%) | (1.9%±0.7%) | |
| 5(3)3, 50° | T1 (ms) | 1174.5±27.7 | 1177.3±29.2 | 1052.6±23.9* | 1059.2±25.6* |
| Difference 1 | (0.6%±1.1%) | (1.0%±1.3%) | (−3.7%±0.9%) | (−3.4%±0.9%) | |
| CoV of 3 schemes 2 | 0.9%±0.5%d | 1.0%±0.5%d | 1.0%±0.7% d | 4.7%±1.0%abc | |
| CoV of 3 FAs 3 | 1.2%±0.6%bcd | 1.6%±0.6%acd | 3.3%±0.6%ab | 2.7%±0.3%ab | |
Mean myocardial T1 fractional difference compared to the standard MOLLI 5(3)3, FA=35° acquisition.
the 3 schemes include 5(3)3, 5(0)3 and 4(1)3(1)2;
the 3 flip angles (FAs) include FA=20°, 35° and 50° using the 5(3)3 acquisition scheme;
For a fair comparison with BLESSPC and InSiL T1 values, the reported T1 values for IG fit and original fit were T1 values after inversion factor correction, which is T1corrected = T1/δ, and δ=0.88.
indicate significant T1 estimation difference compared to the standard MOLLI 5(3)3, FA=35° acquisition (p<0.05),
indicate significant difference compared to BLESSPC (p<0.008),
indicate significant difference compared to InSiL (p<0.008),
indicate significant difference compared to IG fit (p<0.008),
indicate significant difference compared to original fit (p<0.008).