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. Author manuscript; available in PMC: 2017 Jun 5.
Published in final edited form as: Annu Rev Virol. 2016 Aug 25;3(1):237–261. doi: 10.1146/annurev-virology-110615-042301

Figure 6.

Figure 6

Structural mechanism for membrane fusion by coronavirus spikes. (a) Structural mechanism for membrane fusion by class I viral membrane fusion proteins. Schematics of these proteins in both prefusion and postfusion conformations are shown. (b) Negative-stain electron microscopy images of SARS-CoV spike in both prefusion and postfusion conformations are shown (18). (c) Schematics of SARS-CoV postfusion S2 in solution (left) and in vivo (right). Abbreviations: FP, fusion peptide; HR-N, heptad repeat region N; HR-C, heptad repeat region C; IC, intracellular tail; SARS-CoV, severe acute respiratory syndrome coronavirus; TM, transmembrane anchor.