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. 2005 Jan 13;24(2):229–239. doi: 10.1038/sj.emboj.7600487

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(A) K_ATP currents elicited by voltage ramps from −110 to +100 mV to an inside-out patch excised from a Xenopus oocyte expressing Kir6.2ΔC or Kir6.2ΔC-E179M. The dotted line indicates the zero current level. (B) Mean relationship between [ATP] and K_ATP conductance (G), expressed relative to the conductance in the absence of nucleotide (Gc) for Kir6.2ΔC with E179 mutated to N (, n=5), M (, n=5), L (, n=5) and Q (, n=7). The curves are the best fit to equation (1), using values for IC₅₀ and h given in Table I. The dashed line indicates the wild-type data.

Inline graphic — (A) K_ATP currents elicited by voltage ramps from −110 to +100 mV to an inside-out patch excised from a Xenopus oocyte expressing Kir6.2ΔC or Kir6.2ΔC-E179M. The dotted line indicates the zero current level. (B) Mean relationship between [ATP] and K_ATP conductance (G), expressed relative to the conductance in the absence of nucleotide (Gc) for Kir6.2ΔC with E179 mutated to N (, n=5), M (, n=5), L (, n=5) and Q (, n=7). The curves are the best fit to equation (1), using values for IC₅₀ and h given in Table I. The dashed line indicates the wild-type data.