Table 1. Summary of the GWA meta-analysis results for 14 genome-wide significant loci.
| Chr | SNP | Position (bp) | RA | OA |
Meta-analysis (All) |
Meta-analysis (Grade B) |
Associated gene/cytoband | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| RAFEUR | RAFJPT | OR (95% CI) | P value | OR (95% CI) | P value | ||||||
| Previously reported loci | |||||||||||
| 1 | rs12037376 | 22462111 | A | G | 0.17 | 0.58 | 1.16 (1.12–1.19) | 8.87 × 10−17 | 1.28 (1.18–1.36) | 2.69 × 10−9 | WNT4/1p36.12 |
| 2 | rs11674184 | 11721535 | T | G | 0.61 | 0.54 | 1.13 (1.10–1.15) | 2.67 × 10−17 | 1.18 (1.10–1.24) | 1.94 × 10−6 | GREB1/2p25.1 |
| 2 | rs6546324 | 67856490 | A | C | 0.31 | 0.21 | 1.08 (1.05–1.11) | 3.01 × 10−8 | 1.19 (1.11–1.26) | 3.71 × 10−7 | ETAA1/2p14 |
| 2 | rs10167914 | 113563361 | G | A | 0.30 | 0.75 | 1.12 (1.08–1.15) | 1.10 × 10−9 | 1.15 (1.07–1.21) | 7.59 × 10−5 | IL1A/2q13 |
| 4 | rs1903068 | 56008477 | A | G | 0.68 | 0.88 | 1.11 (1.07–1.13) | 1.04 × 10−11 | 1.33 (1.24–1.40) | 2.58 × 10−15 | KDR/4q12 |
| 6 | rs760794 | 19790560 | T | C | 0.43 | 0.71 | 1.09 (1.06–1.12) | 1.79 × 10−10 | 1.17 (1.10–1.24) | 8.74 × 10−7 | ID4/6p22.3 |
| 7 | rs12700667 | 25901639 | A | G | 0.74 | 0.20 | 1.10 (1.07–1.13) | 9.08 × 10−10 | 1.28 (1.19–1.36) | 6.69 × 10−11 | 7p15.2 |
| 9 | rs1537377 | 22169700 | C | T | 0.40 | 0.39 | 1.09 (1.06–1.12) | 1.33 × 10−10 | 1.21 (1.13–1.27) | 6.31 × 10−9 | CDKN2B-AS1/9p21.3 |
| 12 | rs4762326 | 95668951 | T | C | 0.47 | 0.48 | 1.08 (1.05–1.11) | 2.20 × 10−9 | 1.15 (1.08–1.21) | 1.08 × 10−5 | VEZT/12q22 |
| Novel loci | |||||||||||
| 2 | rs1250241 | 216295312 | T | A | 0.29 | 0.06 | 1.06 (1.03–1.09) | 6.20 × 10−5 | 1.23 (1.15–1.30) | 2.99 × 10−9 | FN1/2q35 |
| 6 | rs1971256 | 151816011 | C | T | 0.20 | 0.35 | 1.09 (1.06–1.13) | 3.74 × 10−8 | 1.28 (1.19–1.36) | 1.50 × 10−10 | CCDC170/6q25.1 |
| 6 | rs71575922 | 152554014 | G | C | 0.16 | — | 1.11 (1.07–1.15) | 2.02 × 10−8 | 1.35 (1.24–1.43) | 2.87 × 10−12 | SYNE1/6q25.1 |
| 7 | rs74491657 | 46947633 | G | A | 0.91 | 0.78 | 1.08 (1.03–1.13) | 1.23 × 10−3 | 1.46 (1.28–1.59) | 2.24 × 10−8 | 7p12.3 |
| 11 | rs74485684 | 30242287 | T | C | 0.84 | 0.98 | 1.11 (1.07–1.15) | 2.00 × 10−8 | 1.26 (1.15–1.35) | 7.77 × 10−7 | FSHB/11p14.1 |
Chr, Chromosome; SNP, single-nucleotide polymorphism; Genomic position is shown relative to GRCh37 (hg19); GWA, genome-wide association; RA, risk allele; OA, other allele; OR, odds ratio with respect to RA; CI, confidence interval; RAFEUR, average risk allele frequency in European samples; RAFJPT, average risk allele frequency in Japanese samples.