Study ID | First author, year of publication |
Clinical features and setting | Clinical features: presenting signs and symptoms; index of suspicion for enteric fever (that is, suspected versus unselected febrile); and recent prior antimicrobial treatment. Setting: healthcare facility; country; endemicity; and endemic subspecies. |
Participants | Sample size; age; gender; comorbidities; point of recruitment (in‐patients/ out‐patients); and pregnancy. |
Study design | Whether patients enrolled prospectively or retrospectively. Whether sampling methods were consecutive or random. If the study enrolled more than 1 rapid diagnostic test (RDT), how were tests allocated to individuals or did individuals receive all the tests? Were RDTs used on suspected typhoid/paratyphoid cases or unselected febrile patients? |
Target condition | Typhoid fever or paratyphoid fever, or both |
Reference standard | Which reference standard was used (bone marrow/blood culture/PCR/combination)? Who performed the reference standard test(s)? Where was the test performed? How many repeats were used? Number of observers/operators. Methods of inter‐observer discrepancy resolution. Has the laboratory received quality accreditation by an external agency? |
Index tests |
Salmonella enterica serovars designed to detect Typhi (typhoid), Paratyphi A (paratyphoid), or both. Commercial name. Blood or urine. If blood RDT, capillary or venous blood. Antigen or antibody detection. If antibody detection, subclass detected (that is, IgG/IgM). Format. Transport and storage conditions. Details of test operators, including any special training provided. Where was the test performed? Number of observers/operators and methods of inter‐observer discrepancy resolution. Threshold, that is, what constituted a positive result? |
Data | Numbers of true positives, false positives, true negative, and false negatives. |
Notes | Source(s) of funding |