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. 2017 May 25;2017(5):CD008892. doi: 10.1002/14651858.CD008892.pub2
Study ID First author, year of publication
Clinical features and setting Clinical features: presenting signs and symptoms; index of suspicion for enteric fever (that is, suspected versus unselected febrile); and
recent prior antimicrobial treatment.
Setting: healthcare facility; country; endemicity; and endemic subspecies.
Participants Sample size; age; gender; comorbidities; point of recruitment (in‐patients/ out‐patients); and pregnancy.
Study design Whether patients enrolled prospectively or retrospectively.
Whether sampling methods were consecutive or random.
If the study enrolled more than 1 rapid diagnostic test (RDT), how were tests allocated to individuals or did individuals receive all the tests?
Were RDTs used on suspected typhoid/paratyphoid cases or unselected febrile patients?
Target condition Typhoid fever or paratyphoid fever, or both
Reference standard Which reference standard was used (bone marrow/blood culture/PCR/combination)?
Who performed the reference standard test(s)?
Where was the test performed?
How many repeats were used?
Number of observers/operators.
Methods of inter‐observer discrepancy resolution.
Has the laboratory received quality accreditation by an external agency?
Index tests Salmonella enterica serovars designed to detect Typhi (typhoid), Paratyphi A (paratyphoid), or both.
Commercial name.
Blood or urine.
If blood RDT, capillary or venous blood.
Antigen or antibody detection.
If antibody detection, subclass detected (that is, IgG/IgM).
Format.
Transport and storage conditions.
Details of test operators, including any special training provided.
Where was the test performed?
Number of observers/operators and methods of inter‐observer discrepancy resolution.
Threshold, that is, what constituted a positive result?
Data Numbers of true positives, false positives, true negative, and false negatives.
Notes Source(s) of funding