Dong 2007.

Study characteristics
Patient sampling	Prospective multicentre study as part of a vaccine surveillance programme Healthcare settings: primary, secondary, and tertiary centres (85 in total) Point of recruitment: inpatient and outpatient
Patient characteristics and setting	Countries: China Level of typhoid endemicity (Crump 2004): medium Age: not specified Gender distribution: not specified Entry criteria: aged between 5 and 60 years with a history of fever ≥ 3 days Sample size: 1874
Index tests	Typhidot‐M TUBEX
Target condition and reference standard(s)	Target condition: both Salmonella Typhi and Salmonella Paratyphi A Reference standard: peripheral blood culture (8 mL)
Flow and timing	Prospective multicentre study as part of a vaccine surveillance programme. Index tests performed in real time during patient recruitment.
Comparative
Notes	Reported diagnostic test accuracy for detecting cases of Salmonella Paratyphi A as well as Salmonella Typhi.
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
		Low	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Yes
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Yes
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		Low