Jesudason 2006.

Study characteristics
Patient sampling	Prospective single centre study Healthcare setting: tertiary Point of recruitment: both inpatients and outpatients
Patient characteristics and setting	Countries: India Level of typhoid endemicity (Crump 2004): high Ages: unclear Gender distribution: unclear Entry criteria: clinical suspicion of typhoid fever Sample size: 563
Index tests	Typhidot
Target condition and reference standard(s)	Target condition: Salmonella Typhi Reference standard: peripheral blood culture
Flow and timing	Prospective single centre study. Timing unclear.
Comparative
Notes	Study authors excluded one case of Salmonella paratyphi A.
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Low	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Unclear
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		Low