Khanna 2015.

Study characteristics
Patient sampling	Prospective single centre study Healthcare setting: tertiary Point of recruitment: unclear
Patient characteristics and setting	Countries: India Level of typhoid endemicity (Crump 2004): high Age: mixed Gender distribution: not stated Entry criteria: cases were febrile patients with a positive blood culture for Salmonella Typhi. Healthy afebrile controls
Index tests	TUBEX Typhidot
Target condition and reference standard(s)	Target condition: Salmonella Typhi Reference standard(s): peripheral blood culture (5 mL)
Flow and timing	Prospective single centre study. Timing unclear.
Comparative
Notes	Case control study
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	No
Did the study avoid inappropriate exclusions?	No
		High	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low