Mehmood 2015.

Study characteristics
Patient sampling	Retrospective single centre analysis study Healthcare setting: tertiary Point of recruitment: not stated
Patient characteristics and setting	Countries: Pakistan Level of typhoid endemicity (Crump 2004): high Age: mixed Gender distribution: 59 males/86 females Entry criteria: unselected fever of greater than 3 days
Index tests	Typhidot
Target condition and reference standard(s)	Target condition: Salmonella Typhi Reference standard(s): peripheral blood culture (volume not specified)
Flow and timing	Retrospective analysis of stored samples. Timing unclear.
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Unclear
Did the study avoid inappropriate exclusions?	No
		Low	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low