Prasad 2015.

Study characteristics
Patient sampling	Single centre retrospective analysis study Healthcare setting: tertiary Point of recruitment: both inpatients and outpatients
Patient characteristics and setting	Countries: India Level of typhoid endemicity (Crump 2004): high Age: unclear Gender distribution: unclear Entry criteria: clinical suspicion of enteric fever
Index tests	Typhidot‐M Enteroscreen‐IgM
Target condition and reference standard(s)	Target condition: Salmonella Typhi Reference standard(s): peripheral blood culture (volume not stated)
Flow and timing	Retrospective analysis of stored samples. Timing unclear.
Comparative
Notes	Study authors classified Salmonella Paratyphi blood culture positive cases as disease‐negative.
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	No
Did the study avoid inappropriate exclusions?	Unclear
		High	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		Low