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. 2016 Jun 30;8(19):30817–30829. doi: 10.18632/oncotarget.10339

Figure 1. Expression of SMAD4 is reduced in NSCLC cells and human NSCLC tissues.

Figure 1

(A) SMAD4 mRNA levels in 52 NSCLC tissues and paired noncancerous lung tissues. (B) Box plots showing relative SMAD4 mRNA expression levels of NSCLC tumors and adjacent normal lung tissues in a public data set (GSE19188). (C) Quantitative real-time reverse transcription PCR analysis of SMAD4 mRNA levels in HBE cells and NSCLC cells (A549, H1299, A1650, SPC-A1, H460, 95d, 95C, H226, H520 and SK-MES-1). SMAD4 mRNA levels are expressed as a relative index normalized against the expression of ACTB (β-actin). *P < 0.05; **P < 0.01; ***P < 0.001.