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. 2016 May 26;8(19):30844–30858. doi: 10.18632/oncotarget.9602

Figure 1. High levels of Oct4 expression are correlated with tumor recurrence in patients with high-grade superficial bladder TCC.

Figure 1

A. Immunohistochemical detection of Oct4 expression in three representative tumor sections (scores 0-1, 2, and 3). The immunoreactivity was scored on the basis of the percentage of positive cells (positive staining in <30% (scores 0-1), 30%-70% (score 2), and >70% (score 3) of cells). Negative control slides stained with isotype control mouse IgG were included. B. Kaplan-Meier curves of recurrence-free rate in 110 patients with high (score 3) or low (score 0-2) Oct4 expression. Differences in recurrence-free intervals were analyzed by the log-rank test. C. Representative immunohistochemical staining of Oct4 in paired primary and recurrent tumor specimens. Negative control slides stained with isotype control mouse IgG were included. D. Percentages of primary (n = 12) and recurrent (n = 12) tumors that expressed Oct4 with different scores (P < 0.001, Mann-Whitney U test). E. Relative mRNA levels of Oct4 in human bladder tumor and normal tissue determined by real-time RT-PCR analysis. Values shown are the mean ± SEM (n = 3). Results are representatives of two independent experiments.