Table 4. Multivariable analysis of selected demographic variables and ETS or DpR categorized by cutoff values.

		Progression-free Survival			Overall Survival
		Adjusted for Covariates			Adjusted for Covariates
		HR	95% CI	P	HR	95% CI	P
Age	< 65	Ref			Ref
	≥ 65	0.816	0.433 to 1.540	0.531	0.945	0.441 to 2.026	0.885
ECOG performance status	0	Ref			Ref
	≥ 1	1.689	0.928 to 3.075	0.086	2.404	1.145 to 5.049	0.021
HER2 overexpression by IHC	2+	Ref			Ref
	3+	0.521	0.274 to 0.993	0.048	0.949	0.429 to 2.100	0.897
ETS	< 30%	Ref			Ref
	≥ 30%	0.665	0.371 to 1.193	0.171	0.687	0.332 to 1.423	0.312
Age	< 30%	Ref			Ref
	≥ 65	0.896	0.488 to 1.626	0.720	1.025	0.488 to 2.147	0.950
ECOG performance status	0	Ref			Ref
	≥ 1	1.582	0.861 to 2.915	0.141	2.213	1.045 to 4.675	0.038
HER2 overexpression by IHC	2+	Ref			Ref
	3+	0.587	0.298 to 1.827	0.122	1.224	0.526 to 2.848	0.639
DpR	< 45%	Ref			Ref
	≥ 45%	0.609	0.335 to 1.107	0.104	0.441	0.204 to 0.955	0.038

Abbreviations: HR, hazard ratio; CI, confidence interval; Ref, Reference; ECOG, Eastern Cooperative Oncology Group; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; ETS, early tumor shrinkage; DpR, depth of response