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. 2017 Mar 10;8(19):31187–31198. doi: 10.18632/oncotarget.16102

Figure 2. C-1311 has a p53-dependent effect on cell cycle progression.

Figure 2

(A) HCT116 p53+/+ and p53−/− cells were exposed to C-1311 (0.68 μM and 0.64 μM, respectively) for the times indicated. Western blotting was then carried out for p53, p21, cyclin B1, histone H3 and H3-Ser10. β-actin was used as a loading control. (B) HCT116 p53+/+ and p53−/− cells were exposed to C-1311 as in (A) and DNA content was determined following PI staining by FACS. Histograms are representative of three independent experiments.