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. 2017 Mar 10;8(19):31187–31198. doi: 10.18632/oncotarget.16102

Figure 3. C-1311 induces mitotic catastrophe in p53-deficient cells.

Figure 3

(A) HCT116 p53+/+ and p53−/− cells were exposed to C-1311 (0.68 μM and 0.64 μM, respectively), stained with DAPI and nuclear morphology was analyzed by fluorescent microscopy. Cells containing evenly stained multiple small nuclei were scored as cells undergoing mitotic catastrophe. Representative photographs obtained after 120 h of C-1311 treatment. (B) Quantitation of the percentage of multinucleated cells. The data are presented as mean ± SD, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group.