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. 2017 Mar 10;8(19):31254–31269. doi: 10.18632/oncotarget.16115

Figure 1.

Figure 1

Stat3 Immunohistochemistry (A–C) and Stat3 messenger expression analysis (D). PCNSL section showing a strong Stat3 expression in the tumor cells (A, arrowhead) and in endothelial cells (B, arrow) lining a vessel near a cluster of Stat3 labeled tumor cells (B, arrowhead). Control brain section (C) showing a vessel (arrow) and Stat3 negative tumor cells. RT-PCR analysis (D) showing a significant Stat3 overexpression in PCNSL (2.623 ± SEM 0.305) compared to control brain (1.00 ± SEM 0.011) (**p < 0.001 vs Control). Scale bar: A–B 20 μm, C 40 μm.