Table 1. BRCA1 expression and relationship with clinic pathological factors in nasopharyngeal carcinoma.
Characteristics | BRCA1 expression | ERCC1 expression | ||||||
---|---|---|---|---|---|---|---|---|
N | Positive | Negative | P value1 | N | Positive | Negative | P value1 | |
SEX | ||||||||
Male | 132 | 86 | 46 | 0.757 | 132 | 94 | 38 | 0.154 |
Female | 69 | 43 | 26 | 69 | 42 | 27 | ||
Age(yr) | ||||||||
≤60 | 178 | 119 | 59 | 0.037 | 178 | 118 | 60 | 0.344 |
>60 | 23 | 10 | 13 | 23 | 18 | 5 | ||
WHO pathology classification | ||||||||
I (keratinizing) | 4 | 1 | 3 | 0.069 | 4 | 4 | 0 | <0.001 |
II (nonkeratinizig) | 159 | 99 | 60 | 159 | 96 | 63 | ||
III(undifferentiated) | 38 | 29 | 9 | 38 | 36 | 2 | ||
T stage | ||||||||
T1 | 10 | 8 | 2 | 0.275 | 10 | 5 | 5 | 0.547 |
T2 | 76 | 43 | 33 | 76 | 50 | 26 | ||
T3 | 71 | 47 | 24 | 71 | 49 | 22 | ||
T4 | 44 | 31 | 13 | 44 | 32 | 12 | ||
Lymph node metastasis | ||||||||
N0 | 24 | 15 | 9 | 0.952 | 24 | 18 | 6 | 0.190 |
N1 | 63 | 40 | 23 | 63 | 37 | 26 | ||
N2 | 77 | 50 | 27 | 77 | 57 | 20 | ||
N3 | 37 | 24 | 13 | 37 | 23 | 14 | ||
TNM stage AJCC group (6th ed.) | ||||||||
III | 123 | 75 | 48 | 0.291 | 123 | 86 | 37 | 0.440 |
IV | 78 | 54 | 24 | 78 | 50 | 28 |
1Statistical analysis was estimated by χ2 test, and P < 0.05 was considered statistically significant; WHO, World Health Organization; AJCC, American Joint Committee on Cancer.