Table 4. Association of BRCA1 and ERCC1 and the effect of radiochemotherapy in primary nasopharyngeal carcinoma and cervical lymph node.
Expression | Response | ||||||
---|---|---|---|---|---|---|---|
In primary | N | CR | PR | RR(%) | X2 | P1 | |
BRCA1 | |||||||
+ | 129 | 106 | 22 | 82.1 | 2.071 | 0.209 | |
- | 72 | 65 | 7 | 90.2 | |||
ERCC1 | |||||||
+ | 136 | 113 | 23 | 83.1 | 0.715 | 0.532 | |
- | 65 | 57 | 8 | 87.6 | |||
BRCA1 | ERCC1 | ||||||
+ | + | 103 | 84 | 19 | 81.5 | 4.243 | 0.218 |
- | - | 39 | 37 | 2 | 94.8 | ||
+ | - | 26 | 23 | 3 | 88.4 | ||
- | + | 33 | 28 | 4 | 84.8 | ||
In cervical lymph node | |||||||
BRCA1 | |||||||
+ | 129 | 118 | 11 | 91.4 | 1.356 | 0.387 | |
- | 72 | 69 | 3 | 95 | |||
ERCC1 | |||||||
+ | 136 | 123 | 13 | 90.4 | 3.437 | 0.108 | |
- | 65 | 64 | 1 | 98.4 | |||
BRCA1 | ERCC1 | ||||||
+ | + | 103 | 91 | 12 | 88 | 3.370 | 0.338 |
- | - | 39 | 38 | 1 | 97 | ||
+ | - | 26 | 24 | 2 | 92 | ||
- | + | 33 | 31 | 2 | 93 |
1Statistical analysis was estimated by χ2 test, and P < 0.05 was considered statistically significant; CR, complete response; PR, partial response; RR, response rate.