Table 1A. Characteristics of the included studies (ZEB1).
| Study (year) | Country | Participants | Follow-up(month) | Age | Specimens | Method | Protein/mRNA | Analysis | Endpoints | Cancer Type | Quality Assessment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Bronsert (2014) | German | 59/58 (M/F) | NA | 67 (median) | tissue | IHC | protein | multivariable | OS | pancreatic cancer | 14 |
| Goscinski (2015) | China | 92/59 (M/F) | NA | 33-73 | tissue | IHC | protein | univariable | OS | esophageal squamous cell carcinoma | 12 |
| Hara (2014) | Japan | 79/14 (M/F) | 46 (median) | 64 (mean) | tissue | IHC | protein | univariable | OS | esophageal squamous cell carcinoma | 14 |
| Hashiguchi (2013) | Japan | 85/23 (M/F) | 48.4 (median) | 65.3 (mean) | tissue | IHC | protein | multivariable | OS | hepatocellular carcinoma | 16 |
| Kurahara (2012) | Japan | 52/24 (M/F) | NA | 67 (median) | tissue | IHC | protein | univariable | OS | pancreatic cancer | 13 |
| Murai (2014) | Japan | 83/33 (M/F) | 37 (median) | 64 (mean) | tissue | qRT-PCR | mRNA | univariable | OS | gastric cancer | 16 |
| Okugawa (2012) | Japan | 106/28 (M/F) | 23 (median) | 67 (mean) | tissue | qRT-PCR | mRNA | multivariable | OS | gastric cancer | 14 |
| Singh (2011) | America | 136/114 (M/F) | 0.4-142.6 | 64.6 (mean) | tissue | gene chip | mRNA | univariable | OS | colonrectal cancer | 9 |
| Terashita (2016) | Japan | 63/39 (M/F) | 35 (median) | NA | tissue | IHC | protein | multivariable | OS | cholangiocarcinoma | 16 |
| Wu (2016) | China | 145 (total) | 47.7 (median) | NA | tissue | IHC | protein | multivariable | OS, RFS | colonrectal cancer | 17 |
| Yang X. (2014) | China | 68/32 (M/F) | 32 (median) | 50 (median) | tissue | IHC | protein | univariable | OS | esophageal squamous cell carcinoma | 16 |
| Zhang (2013) | China | 50/42 (M/F) | NA | 62 (mean) | tissue | qRT-PCR | mRNA | multivariable | OS | colonrectal cancer | 16 |
| Zhou L. (2016) | China | 172/89 (M/F) | 8-110 | NA | tissue | IHC | protein | multivariable | OS | gastric cancer | 16 |
| Zhou Y. (2012) | China | 98/12 (M/F) | NA | 54 (median) | tissue | western blot | protein | multivariable | OS, DFS | hepatocellular carcinoma | 13 |
| Zhou Y. (2012) | China | 98/12 (M/F) | NA | 54 (median) | tissue | western blot | protein | multivariable | OS, DFS | hepatocellular carcinoma | 13 |
| Zhou Y. (2012) | China | 98/12 (M/F) | NA | 54 (median) | tissue | western blot | protein | multivariable | OS, DFS | hepatocellular carcinoma | 13 |
M: male; F: female; NA: not available; IHC: immunohistochemistry; qRT-PCR: quantitative real time polymerase chain reaction; OS: overall survival; RFS: recurrence free survival; DFS: disease free survival.