Table 1B. Characteristics of the included studies (ZEB2).
| Study (year) | Country | Participants | Follow-up(month) | Age | Specimens | Method | Protein/mRNA | Analysis | Endpoints | Cancer Type | Quality Assessment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cai (2012) | China | 220/28 (M/F) | 26.0 (median) | 47.8 (mean) | tissue | IHC | protein | multivariabe | OS | hepatocellular carcinoma | 17 |
| Dai (2012) | China | 50/26 (M/F) | 40 (median) | 53.8 (mean) | tissue | IHC | protein | Univariable | OS | gastric cancer | 14 |
| Kahlert (2011) | German | 121/54 (M/F) | 124 (median) | NA | tissue | IHC | protein | multivariabe | DFS | colorectal cancer | 14 |
| Kurahara (2012) | Japan | 52/24 (M/F) | NA | 67 (median) | tissue | IHC | protein | univariable | OS | pancreatic cancer | 13 |
| Okugawa (2013) | Japan | 106/28 (M/F) | 23 (median) | 67 (mean) | tissue | qRT-PCR | mRNA | multivariabe | OS | gastric cancer | 15 |
| Otsuki (2011) | Japan | 84/22 (M/F) | 48 (median) | NA | tissue | qRT-PCR | mRNA | univariable | DFS, RFS | gastric cancer | 15 |
| Sun (2015) | Chian | 192/69 (M/F) | 50 (median) | 59 (mean) | tissue | IHC | protein | univariable | OS, DFS | gastric cancer | 17 |
| Techasen (2014) | Thailand | 149/66 (M/F) | NA | 21-82 | tissue | IHC, qRT-PCR | protein, mRNA | univariable | OS | cholangiocarcinoma | 13 |
| Xia-cohort I (2014) | China | 581/109 (M/F) | 4-96 | 51.8 (mean) | tissue | IHC | protein | univariable | OS | hepatocellular carcinoma | 15 |
| Xia-cohort II (2014) | China | 256/56 (M/F) | 4-96 | 51.9 (mean) | tissue | IHC | protein | univariable | OS | hepatocellular carcinoma | 15 |
| Yang Z. (2015) | China | 79/13 (M/F) | NA | NA | tissue | IHC | protein | univariable | OS | hepatocellular carcinoma | 11 |
| Yoshida (2015) | Japan | 100/11 (M/F) | NA | 64.3 (mean) | tissue | IHC | protein | univariable | OS, DFS | esophageal squamous cell carcinoma | 12 |
| Yoshida (2015) | Japan | 100/11 (M/F) | NA | 64.3 (mean) | tissue | IHC | protein | univariable | OS, DFS | esophageal squamous cell carcinoma | 12 |
| Yoshida (2015) | Japan | 100/11 (M/F) | NA | 64.3 (mean) | tissue | IHC | protein | univariable | OS, DFS | esophageal squamous cell carcinoma | 12 |
M: male; F: female; NA: not available; IHC: immunohistochemistry; qRT-PCR: quantitative real time polymerase chain reaction; OS: overall survival; RFS: recurrence free survival; DFS: disease free survival.