Table 2. Association between FAM13C expression and Ki67-labeling index in all prostate cancers and subsets defined by Gleason score, ERG fusion, and PTEN deletion status.
FAM13C IHC | n | Ki67 Li (mean) | Sth.deviation | |
---|---|---|---|---|
all p < 0.0001 |
negative | 1,991 | 2.1 | 0.06 |
weak | 837 | 2.8 | 0.09 | |
moderate | 1,368 | 2.9 | 0.07 | |
strong | 1,615 | 3.6 | 0.07 | |
pGleason ≤ 3 + 3 p < 0.0001 |
negative | 549 | 1.7 | 0.09 |
weak | 158 | 2.5 | 0.16 | |
moderate | 288 | 2.5 | 0.12 | |
strong | 298 | 2.7 | 0.12 | |
pGleason 3 + 4 p < 0.0001 |
negative | 1,182 | 2.1 | 0.07 |
weak | 520 | 2.8 | 0.10 | |
moderate | 801 | 2.9 | 0.08 | |
strong | 887 | 3.4 | 0.08 | |
pGleason 4 + 3 p < 0.0001 |
negative | 198 | 2.7 | 0.25 |
weak | 121 | 2.9 | 0.32 | |
moderate | 219 | 3.6 | 0.24 | |
strong | 311 | 4.2 | 0.20 | |
pGleason ≥ 4 + 4 p = 0.0143 |
negative | 53 | 3.4 | 0.60 |
weak | 34 | 3.6 | 0.75 | |
moderate | 52 | 4.4 | 0.61 | |
strong | 109 | 5.5 | 0.42 | |
PTEN normal p < 0.0001 |
negative | 955 | 2.5 | 0.09 |
weak | 453 | 3.0 | 0.13 | |
moderate | 711 | 3.1 | 0.10 | |
strong | 902 | 3.6 | 0.09 | |
PTEN deleted p = 0.0002 |
negative | 69 | 2.9 | 0.35 |
weak | 76 | 3.3 | 0.34 | |
moderate | 187 | 3.3 | 0.21 | |
strong | 328 | 4.2 | 0.16 | |
ERG negative p < 0.0001 |
negative | 1,537 | 1.9 | 0.07 |
weak | 464 | 3.0 | 0.13 | |
moderate | 589 | 3.2 | 0.11 | |
strong | 531 | 3.9 | 0.12 | |
ERG positive p < 0.0001 |
negative | 424 | 2.5 | 0.12 |
weak | 357 | 2.6 | 0.13 | |
moderate | 747 | 2.8 | 0.09 | |
strong | 1,060 | 3.4 | 0.08 |