Table 4. Univariate and multivariate analyses of the prognostic influence of clinicopathological factors on overall survival.
Clinicopathological features | median OS (month) | Univariate analyses | Multivariate analyses | |||||||
---|---|---|---|---|---|---|---|---|---|---|
OS (%) | χ2 | P | HR | 95.0% CI for HR | P | |||||
1year | 3year | 5year | low | high | ||||||
ECOG performance status | ||||||||||
(0,1) | 72.00 | 90.80 | 65.52 | 24.14 | 0.019 | 0.891 | ||||
(2,3) | 72.00 | 95.24 | 64.28 | 35.71 | ||||||
Age (y) | ||||||||||
<50 | 72.00 | 94.55 | 69.09 | 29.09 | 2.375 | 0.123 | ||||
≥50 | 70.89 | 90.54 | 62.16 | 27.03 | ||||||
Stage | ||||||||||
II | 72.00 | 96.72 | 68.85 | 26.23 | 3.210 | 0.073 | ||||
III | 72.00 | 88.24 | 61.76 | 29.41 | ||||||
Lymph nodes metastases | ||||||||||
No | 72.00 | 100.00 | 85.71 | 48.57 | 31.257 | 0.000 | 0.869 | 0.411 | 1.835 | 0.712 |
Yes | 32.77 | 84.75 | 40.68 | 3.39 | ||||||
Differentiation | ||||||||||
Well-moderate | 72.00 | 93.55 | 58.06 | 25.81 | 0.028 | 0.867 | ||||
Poor | 72.00 | 91.04 | 71.64 | 29.85 | ||||||
Tumor size | ||||||||||
≥5.7cm | 53.24 | 87.95 | 48.19 | 16.87 | 23.076 | 0.000 | 2.646 | 0.987 | 7.092 | 0.053 |
<5.7cm | 72.00 | 100.00 | 95.65 | 47.83 | ||||||
SCC-ag level (ng/ml) | ||||||||||
<2 | 70.99 | 97.92 | 62.50 | 31.25 | 1.101 | 0.577 | ||||
2-10 | 72.00 | 84.91 | 66.04 | 24.53 | ||||||
>10 | 72.00 | 96.43 | 67.86 | 28.57 | ||||||
Hb level (g/dl) | ||||||||||
<10 | 72.00 | 91.49 | 71.28 | 29.79 | 6.466 | 0.004 | 0.704 | 0.389 | 1.276 | 0.247 |
≥10 | 48.95 | 94.29 | 48.57 | 22.86 | ||||||
Treatment | ||||||||||
Radiation | 72.00 | 90.54 | 62.16 | 22.97 | 0.009 | 0.925 | ||||
Concurrent Chemoradiation | 72.00 | 94.55 | 69.09 | 34.55 | ||||||
AURKA IHC | ||||||||||
High | 38.44 | 86.30 | 42.47 | 5.48 | 44.402 | 0.000 | 9.091 | 2.597 | 32.258 | 0.001 |
Low | 72.00 | 100.00 | 94.64 | 57.14 |