Table 1. Tumor-initiating ability of endometrial cancer cell and ovarian cancer cells.
| Cells | Injected cell number | ||||||
|---|---|---|---|---|---|---|---|
| 102 | 103 | 104 | CSC frequency | 95% CI | P value | ||
| HEC-1 | ALDHhighcells | 0/11 | 5/11 | 10/11 | 1 in 3082 | 1546–6145 | *0.000258 |
| ALDHlowcells | 0/11 | 1/11 | 4/11 | 1 in 19987 | 8195–48748 | ||
| control siRNA | - | 3/5 | - | ||||
| HSF1 siRNA-i | - | 0/5 | - | ||||
| HSF1 siRNA-ii | - | 0/5 | - | ||||
| MCAS | ALDHhighcells | 0/5 | 0/5 | 5/5 | 1 in 4326 | 1640–11415 | 0.0519 |
| ALDHlowcells | 0/5 | 0/5 | 2/5 | 1 in 22379 | 5622–89084 | ||
| HTBoA | ALDHhighcells | 0/5 | 0/5 | 3/5 | 1 in 12859 | 4134–39996 | *0.0214 |
| ALDHlowcells | 0/5 | 0/5 | 0/5 | - | 18527- | ||
The tumor-initiating abilities were evaluatad at day 70 post cell injection. Data are expressed as number of tumors formed/number of injections. Differences of estimated frequencies of CICs were analyzed by Chi-square test. CSC frequencies were calclutated at ELDA web site (http://bioinf.wehi.edu.au/software/elda/). *P < 0.05.