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. 2017 Mar 18;8(19):31601–31611. doi: 10.18632/oncotarget.16364

Figure 4. Azithromycin (AZM) augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in lung homogenates of exacerbating mice.

Figure 4

Mice were challenged with HDM 3 days/week for 3 weeks and were subsequently exposed daily for 3 days to poly(I:C) or saline. Mice were treated once daily with azithromycin or vehicle starting 48h before and continuing throughout the poly(I:C) challenges. Gene expression levels of Mx1 (A), viperin (B), MDA5 (C) and RIG-I (D) were measured in lung homogenates by real-time PCR and data is presented as mean ± standard error of the mean (SEM) fold change of HDM/saline/vehicle relative to 18S rRNA expression. Comparison of different groups was performed by Kruskal-Wallis with Wilcoxon post testing. *p < 0.05, **p < 0.01 vehicle vs. AZM. 5-9 mice per group.