Table 1. Associations between 28 methylated genes detected in blood samples and NSCLC.

Gene	Studies	Overall OR (95% CI)	I2; P	P-value	Cases	Controls	P (Egger's test)
P16	13	17.28 (10.33–28.92)	32.5%; 0.122	< 0.001	903	587	0.018
RASSF1A	11	16.41 (6.68–40.33)	50.4%; 0.028	< 0.001	770	444	0.016
APC	7	14.01 (4.30–45.67)	58.9%; 0.024	< 0.001	563	314	0.088
RARB	7	7.94 (2.70–23.34)	72.5%; 0.001	< 0.001	591	436	0.001
DAPK	5	30.78 (8.86–106.96)	0.0%; 0.618	< 0.001	385	237	NA
CDH13	5	12.63 (2.90–55.07)	64.1%; 0.025	0.001	338	187	NA
FHIT	4	4.23 (0.87–20.49)	79.3%; 0.002	0.073	290	186	NA
MGMT	4	15.29 ( 4.33–54.04)	0.0%; 0.680	< 0.001	267	129	NA
DCC	3	11.44 ( 5.09 - 25.71)	0.0%; 0.531	< 0.001	205	180	NA
P14	2	8.95 (1.70–47.19)	0.0%; 0.738	0.01	199	34	NA
CDH1	2	3.97 (1.66–9.46)	0.0%; 0.795	0.002	96	40	NA
RUNX3	2	45.64 (5.89–353.72)	0.0%; 0.654	< 0.001	82	56	NA
BLU	2	1.63 (0.95–2.78)	12.1%; 0.286	0.073	143	116	NA
SFRP1	1	7.43 (1.69–32.68)	NA; NA	0.008	110	50	NA
TMS1	1	27.80 (1.61–479.59)	NA; NA	0.022	62	46	NA
TIMP3	1	35.87 (2.12–607.48)	NA; NA	0.013	110	110	NA
DLEC1	1	16.73 (2.21–126.86)	NA; NA	0.006	110	50	NA
EFEMP1	1	4.37 (1.25–15.29)	NA; NA	0.021	110	50	NA
Dkk3	1	27.43 (7.93–94.86)	NA; NA	< 0.001	75	75	NA
BRMS1	1	45.16 (2.60–784.96)	NA; NA	0.009	48	24	NA
KLK10	1	9.85 (2.26–42.96)	NA; NA	0.002	110	50	NA
RASSF2	1	59.18 (3.48–1005.20)	NA; NA	0.005	62	46	NA
DCLK1	1	6.991 (2.74–17.82)	NA; NA	< 0.001	46	95	NA
AIM1	1	6.55 (0.82 - 52.21)	NA; NA	0.076	76	30	NA
hOGG1	1	3.58 (1.34–9.58)	NA; NA	0.011	80	80	NA
KIF1A	1	18.02 (2.29–141.69)	NA; NA	0.006	70	80	NA
NISCH	1	2.12 (1.06–4.25)	NA; NA	0.034	70	80	NA
SEMA3B	1	11.53 (4.73–28.10)	NA; NA	< 0.001	80	80	NA

Abbreviations: NA: not applicable.