Figure 1.

L-655,708 produced a sustained antidepressant-like effect that is mediated by the vHipp. Two separate cohorts of rats were injected with L-655,708 (3 mg/kg, i.p.) or vehicle (50% propylene glycol). The FST was used to detect antidepressant-like efficacy 30 minutes (A) or 1 week (B) following drug treatment. *P < .05, Student’s t test. (C) Lidocaine into the vHipp blocked antidepressant-like effects of L-655,708 at 1 week. Rats were implanted with stainless steel cannulae targeting the vHipp and administered either vehicle (aCSF) or lidocaine (2%, 5 μL) directly into the vHipp followed by the systemic administration of L-655,708 (3 mg/kg, i.p.) or vehicle. The FST was used to detect antidepressant-like effects 1 week following drug treatment. *P<.05 vs vehicle-vehicle; #P<.05 vs L-655,708-vehicle, Holm-Sidak’s posthoc analysis. n=8 rats/group.