Figure 2.
Manhattan plot for the RR-interval discovery meta-analysis in European individuals. The Manhattan plot displays the results from the discovery meta-analysis of RR-intervals from N = 104,452 individuals of European ancestry (from 30 cohorts). On the X axis, P-values are expressed as −log10(P) are plotted according to physical genomic locations by chromosome. The Y-axis is truncated to −log10(P) = 20 with any variants with P < 1 × 10−20 displayed on the −log10(P) = 20 line. The nine novel variants validated from the combined meta-analysis with UK Biobank data are represented by squares. Variants in linkage disequilibrium (LD; r2 > 0.8) with published GWAS variants are highlighted with black circles (12). New secondary variants validated in our analysis are indicated as triangles. Locus names of the novel loci correspond to the nearest annotated gene, with 5p13.3 denoting an intergenic variant. The dashed line indicates a P-value threshold of 1 × 10−5, corresponding to the lookup significance threshold and the continuous line indicates a P-value threshold of 2 × 10−7, corresponding to exome-wide significance.