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. 2005 Jan 11;102(4):1127–1132. doi: 10.1073/pnas.0408288102

Fig. 2.

Fig. 2.

DC but not Kupffer cell depletion results in diminished Th1 cytokine production in response to α-GalCer or α-C-GalCer administration. (A) Groups of five DTR Tg mice were injected with DT or PBS and, 12 h later, were treated with 1 μgof α-GalCer or α-C-GalCer. Blood samples were taken for ELISA analyses of IFN-γ and IL-12 concentrations in the sera of the mice 2, 6, 12, 24, 48, and 72 h after glycolipid injection. One representative experiment of three is shown. (B) Groups of five WT mice were injected with clodronate-loaded liposomes (CL2) or PBS-loaded liposomes (PBS) and, 48 h later, were treated with 1 μgof α-GalCer or α-C-GalCer. Blood samples were taken for ELISA analyses of IFN-γ and IL-12 concentrations in the sera of the mice 2, 6, 12, 24, 48, and 72 h after glycolipid injection. The data are expressed as the average ± SD of two different dilutions of pooled sera. One representative experiment of two is shown.