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. 2017 Jun 5;15:101. doi: 10.1186/s12916-017-0851-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Description of DNA methylation dynamics across melanoma progression. a Two-dimensional clustering analysis was performed on all samples (n = 75). Probes are in rows; samples (green, nevi; yellow, primary melanomas; blue, metastases) in columns. Note that both gains and losses of DNA methylation changes occur across stages. b Distribution of tumor-specific DNA methylation changes in all genomic compartments: promoter, body, 3'UTR, and gene-body, and in varying CpG content and neighborhood context classified in island, shore, shelf, and open-sea. c Distribution of metastasis-specific DNA methylation changes in all genomic compartments: promoter, body, 3'UTR, and gene-body and in varying CpG content and neighborhood context classified in island, shore, shelf, and open-sea. d DAVID functional annotation of the most significant biological process categories within the hyper- (right panel) and hypomethylated (left panel) genes showing a negative correlation between DNA methylation and gene expression values (primary primary tumors, meta metastases; P < 0.01)