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. 2017 May 25;8:15201. doi: 10.1038/ncomms15201

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Copyright © 2017, The Author(s)

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(a) Immunofluorescent staining for C2C12 myotubes showed that overexpression of IGF-1 or PI3K(p85α) reduced muscle atrophy induced by miR-29b mimic (n=4 per group, scale bar, 100 μm). (b) qRT–PCR analysis showed that overexpression of IGF-1 or PI3K(p85a) reduced miR-29b-induced upregulation of Atrogin-1 and Murf-1 in C2C12 myotubes (n=6 per group). Error bars, s.e.m. One-way ANOVA test was performed to compare multiple groups followed by Bonferroni's post hoc test. *P<0.05, **P<0.01.