Skip to main content
. Author manuscript; available in PMC: 2017 Jun 5.
Published in final edited form as: Enzymes. 2016 Mar 28;39:293–323. doi: 10.1016/bs.enz.2016.02.002

Fig. 9.

Fig. 9

Conserved structural motif D as a target for viral attenuation and vaccine development. (A) Conservation of the motif D lysine in viral RdRps. (B) K359R PV exhibits a delayed growth phenotype. (C) K359R PV is attenuated. (D) K359R PV elicits a protective immune response. Adapted from S.A. Weeks, C.A. Lee, Y. Zhao, E.D. Smidansky, A. August, J.J. Arnold, C.E. Cameron, A polymerase mechanism-based strategy for viral attenuation and vaccine development, J. Biol. Chem. 287 (38) (2012) 31618–31622.