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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2017 Jun;16(6):981–990. doi: 10.1158/1535-7163.MCT-16-0592

Figure 3. Chemical structures of the current compounds identified as inhibitors of CtBP1 transcriptional activity.

Figure 3

(A) NSC95397 was discovered through high-throughput screening. (B) 2-keto-4-methylthiobutyrate (MTOB) was identified through screening known substrates of other dehydrogenases. (C) Phenylpyruvate and 2-hydroxyimino-3-phenylproanoic acid are MTOB derivatives generated through structure-based design. (D) The cyclic peptide-61 (CP61) amino acid sequence identified from screening a cyclic peptide library.