Figure 4.

Combinatorial Chemovirotherapeutic Treatment of Four Different Pancreatic Tumor Cell Lines with GLV-1h68 and Gemcitabine

Gemcitabine was added after infection with GLV-1h68 at either 1 or 24 hpi. The remaining tumor cell masses were analyzed by sulforhodamine B assays (n = 1, mean and SD are shown). The additional effect of the combination treatment was compared with the effect of both monotherapeutic treatment regimens, respectively. Dotted lines indicate a tumor cell mass of 75% being remnant at 72 hpi. Gem, gemcitabine; hpi, hour(s) post-infection; MOCK, untreated control; MOI, multiplicity of infection.